This title now updated: the definitive neuroscience resource-from Eric R. Kandel, MD (winner of the Nobel Prize in 2000); James H. Schwartz, MD, PhD; Thomas M. Jessell, PhD; Steven A. Siegelbaum, PhD; and A. J. Hudspeth, PhD 900 full-color illustrations. Deciphering the link between the human brain and behavior has always been one of the most intriguing - and often challenging-aspects of scientific endeavor. The sequencing of the human genome, and advances in molecular biology, have illuminated the pathogenesis of many neurological diseases and have propelled our knowledge of how the brain controls behavior. To grasp the wider implications of these developments and gain a fundamental understanding of this dynamic, fast-moving field, Principles of Neuroscience stands alone as the most authoritative and indispensible resource of its kind. In this classic text, prominent researchers in the field expertly survey the entire spectrum of neural science, giving an up-to-date, unparalleled view of the discipline for anyone who studies brain and mind. Here, in one remarkable volume, is the current state of neural science knowledge - ranging from molecules and cells, to anatomic structures and systems, to the senses and cognitive functions-all supported by more than 900 precise, full-color illustrations. In addition to clarifying complex topics, the book also benefits from a cohesive organization, beginning with an insightful overview of the interrelationships between the brain, nervous system, genes, and behavior. Principles of Neural Science then proceeds with an in-depth examination of the molecular and cellular biology of nerve cells, synaptic transmission, and the neural basis of cognition. The remaining sections illuminate how cells, molecules, and systems give us sight, hearing, touch, movement, thought, learning, memories, and emotions. The new fifth edition of Principles of Neural Science is thoroughly updated to reflect the tremendous amount of research, and the very latest clinical perspectives, that have significantly transformed the field within the last decade. Ultimately, Principles of Neural Science affirms that all behavior is an expression of neural activity, and that the future of clinical neurology and psychiatry hinges on the progress of neural science. Far exceeding the scope and scholarship of similar texts, this unmatched guide offers a commanding, scientifically rigorous perspective on the molecular mechanisms of neural function and disease-one that you'll continually rely on to advance your comprehension of brain, mind, and behavior. Features: the cornerstone reference in the field of neuroscience that explains how the nerves, brain, and mind function; clear emphasis on how behavior can be examined through the electrical activity of both individual neurons and systems of nerve cells; current focus on molecular biology as a tool for probing the pathogenesis of many neurological diseases, including muscular dystrophy, Huntington disease, and certain forms of Alzheimer's disease; more than 900 engaging full-color illustrations - including line drawings, radiographs, micrographs, and medical photographs clarify often-complex neuroscience concepts; outstanding section on the development and emergence of behavior, including important coverage of brain damage repair, the sexual differentiation of the nervous system, and the aging brain. Features: more detailed discussions of cognitive and behavioral functions, and an expanded review of cognitive processes; a focus on the increasing importance of computational neural science, which enhances our ability to record the brain's electrical activity and study cognitive processes more directly; and chapter-opening. Key concepts: provides a convenient, study-enhancing introduction to the material covered in each chapter; selected readings and full reference citations at the close of each chapter facilitate further study and research; and helpful appendices highlight basic circuit theory; the neurological examination of the patient; circulation of the brain; the blood-brain barrier, choroid plexus, and cerebrospinal fluid; neural networks; and theoretical approaches to neuroscience. (Quelle: amazon.de)
Aus dem Inhalt: Contents xiii / Preface xli / Acknowledgments xliii / Contributors xlv // Part I / Overall Perspective / 1 The Brain and Behavior 5 / 2 Nerve Cells, Neural Circuitry, and Behavior 21 / 3 Genes and Behavior 39 // Part II / Cell and Molecular Biology of the Neuron / 4 The Cells of the Nervous System 71 / 5 Ion Channels 100 / 6 Membrane Potential and the Passive Electrical Properties of the Neuron 126 / 7 Propagated Signaling: The Action Potential 148 // Part III / Synaptic Transmission / 8 Overview of Synaptic Transmission 177 / 9 Signaling at the Nerve-Muscle Synapse: Directly Gated Transmission 189 / 10 Synaptic Integration in the Central Nervous System 210 / 11 Modulation of Synaptic Transmission: Second Messengers 236 / 12 Transmitter Release 260 / 13 Neurotransmitters 289 / 14 Diseases of the Nerve and Motor Unit 307 // Part IV / The Neural Basis of Cognition / 15 The Organization of the Central Nervous System 337 / 16 The Functional Organization of Perception and Movement 356 / 17 From Nerve Cells to Cognition: The Internal Representations of Space and Action 370 / 18 The Organization of Cognition 392 / 19 Cognitive Functions of the Premotor Systems 412 / 20 Functional Imaging of Cognition 426 // Part V / Perception / 21 Sensory Coding 449 / 22 The Somatosensory System: Receptors and Central Pathways 475 / 23 Touch 498 / 24 Pain 530 / 25 The Constructive Nature of Visual Processing 556 / 26 Low-Level Visual Processing: The Retina 577 / 27 Intermediate-Level Visual Processing and Visual Primitives 602 / 28 High-Level Visual Processing: Cognitive Influences 621 / 29 Visual Processing and Action 638 / 30 The Inner Ear 654 / 31 The Auditory Central Nervous System 682 / 32 Smell and Taste: The Chemical Senses 712 // Part VI / Movement / 33 The Organization and Planning of Movement 743 / 34 The Motor Unit and Muscle Action 768 / 35 Spinal Reflexes 790 / 36 Locomotion 812 / 37 Voluntary Movement: The Primary Motor Cortex 835 / 38 Voluntary Movement: The Parietal and Premotor Cortex 865 / 39 The Control of Gaze 894 / 40 The Vestibular System 917 / 41 Posture 935 / 42 The Cerebellum 960 / 43 The Basal Ganglia 982 / 44 Genetic Mechanisms in Degenerative Diseases of the Nervous System 999 // Part VII / The Unconscious and Conscious Processing of Neural Information / 45 The Sensory, Motor, and Reflex Functions of the Brain Stem 1019 / 46 The Modulatory Functions of the Brain Stem 1038 / 47 The Autonomie Motor System and the Hypothalamus 1056 / 48 Emotions and Feelings 1079 / 49 Homeostasis, Motivation, and Addictive States 1095 / 50 Seizures and Epilepsy 1116 / 51 Sleep and Dreaming 1140 // Part VIII / Development and the Emergence of Behavior / 52 Patterning the Nervous System 1165 / 53 Differentiation and Survival of Nerve Cells 1187 / 54 The Growth and Guidance of Axons 1209 / 55 Formation and Elimination of Synapses 1233 / 56 Experience and the Refinement of Synaptic Connections 1259 / 57 Repairing the Damaged Brain 1284 / 58 Sexual Differentiation of the Nervous System 1306 / 59 The Aging Brain 1328 // Part IX / Language, Thought, Affect, and Learning / 60 Language 1353 / 61 Disorders of Conscious and Unconscious Mental Processes 1373 / 62 Disorders of Thought and Volition: Schizophrenia 1389 / 63 Disorders of Mood and Anxiety 1402 / 64 Autism and Other Neurodevelopmental Disorders Affecting Cognition 1425 / 65 Learning and Memory 1441 / 66 Cellular Mechanisms of Implicit Memory Storage and the Biological Basis of Individuality 1461 / 67 Prefrontal Cortex, Hippocampus, and the Biology of Explicit Memory Storage 1487 // Appendices / A Review of Basic Circuit Theory 1525 / B The Neurological Examination of the Patient 1533 / C Circulation of the Brain 1550 / D The Blood-Brain Barrier, Choroid Plexus, and Cerebrospinal Fluid 1565 / E Neural Networks 1581 / F Theoretical Approaches to Neuroscience: Examples from Single Neurons to Networks 1601 / Index 1619
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2013
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New York, NY [u.a.], McGraw-Hill Professional
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0-07-139011-1
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5. ed., L, 1709 S. : zahlr. Ill., graph. Darst.
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