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'The Code Breaker's confident, cinematic style makes Crispr accessible like never before, taking readers on a journey that is exciting, as well as ethically treacherous.' - The Financial Times

 

'A page-turner. It weaves history and contemporary events into a narrative propelled by the career of its protagonist, Jennifer Doudna.' - The Economist

 

`Nobody knows this stuff and these people, and explains them, quite like Isaacson. If you need to know about CRISPR - and you do - this is the place to start.' - The Sunday Times

 

The best-selling author of Leonardo da Vinci and Steve Jobs returns.

 

In 2012, Nobel Prize winning scientist Jennifer Doudna hit upon an invention that will transform the future of the human race: an easy-to-use tool that can edit DNA.

 

Known as CRISPR, it opened a brave new world of medical miracles and moral questions. It has already been deployed to cure deadly diseases, fight the coronavirus pandemic of 2020, and make inheritable changes in the genes of babies.

 

But what does that mean for humanity? Should we be hacking our own DNA to make us less susceptible to disease? Should we democratise the technology that would allow parents to enhance their kids?

 

After discovering this CRISPR, Doudna is now wrestling these even bigger issues.

 

The Code Breaker is an examination of how life as we know it is about to change - and a brilliant portrayal of the woman leading the way.

 

'The Code Breaker's confident, cinematic style makes Crispr accessible like never before, taking readers on a journey that is exciting, as well as ethically treacherous.' The Financial Times

 

'The CRISPR history holds obvious appeal for Walter Isaacson, a biographer of Albert Einstein, Benjamin Franklin, Steve Jobs and Leonardo da Vinci. In "The Code Breaker" he reprises several of his previous themes - science, genius, experiment, code, thinking different - and devotes a full length book to a female subject for the first time. Jennifer Doudna, a genuine heroine for our time, may be the code breaker of the book's title, but she is only part of Isaacson's story... The Code Breaker' is in some respects a journal of our 2020 plague year. By the final chapter, Isaacson has enrolled in a vaccine trial' - New York Times

 

`Nobody knows this stuff and these people, and explains them, quite like Isaacson. If you need to know about CRISPR - and you do - this is the place to start' - The Sunday Times

 

 

Contents:

INTRODUTION Into the Breach xiii / / Part One: The Origins of Life / CHAPTER 1 Hilo 3 / CHAPTER 2 The Gene 11 / CHAPTER 3 DNA 17 / CHAPTER 4 The Education of a Biochemist 29 / CHAPTER 5 The Human Genome 37 / CHAPTER 6 RNA 43 / CHAPTER 7 Twists and Folds 51 / CHAPTER 8 Berkeley 63 / / Part Two: CRISPR / CHAPTER 9 Clustered Repeats 71 / CHAPTER 10 The Free Speech Movement Café 79 / CHAPTER 11 Jumping In / CHAPTER 12 The Yogurt Makers / CHAPTER 13 Genentech / CHAPTER 14 The Lab / CHAPTER 15 Caribou / / CHAPTER 16 Emmanuelle Charpentier / CHAPTER 17 CRISPR-Cas9 / CHAPTER 18 Science, 2012 / CHAPTER 19 Dueling Presentations / / / Part Three: Gene Editing / CHAPTER 20 A Human Tool 153 / CHAPTER 21 The Race / CHAPTER 22 Feng Zhang / CHAPTER 23 George Church / CHAPTER 24 Zhang Tackles CRISPR / CHAPTER 25 Doudna Joins the Race / CHAPTER 26 Photo Finish / CHAPTER 27 Doudna's Final Sprint / CHAPTER 28 Forming Companies / CHAPTER 29 Mon Amie / CHAPTER 30 The Heroes of CRISPR / CHAPTER 31 Patents / / Part Four: CRISPR in Action / CHAPTER 32 Therapies / CHAPTER 33 Biohacking / CHAPTER 34 DARPA and Anti-CRISPR / / Part Five: Public Scientist / CHAPTER 35 Rules of the Road / CHAPTER 36 Doudna Steps In / / Part Six: CRISPR Babies / CHAPTER 37 He Jiankui / CHAPTER 38 The Hong Kong Summit / CHAPTER 39 Acceptance / / Part Seven: The Moral Questions / CHAPTER 40 Red Lines / CHAPTER 41 Thought Experiments / CHAPTER 42 Who Should Decide? / CHAPTER 43 Doudna's Ethical Journey / / Part Eight: Dispatches from the Front / CHAPTER 44 Quebec / CHAPTER 45 I Learn to Edit / CHAPTER 46 Watson Revisited / CHAPTER 47 Doudna Pays a Visit / / Part Nine: Coronavirus / CHAPTER 48 Call to Arms / CHAPTER 49 Testing / CHAPTER 50 The Berkeley Lab / CHAPTER 51 Mammoth and Sherlock / CHAPTER 52 Coronavirus Tests / CHAPTER 53 Vaccines / CHAPTER 54 CRISPR Cures / CHAPTER 55 Cold Spring Harbor Virtual / CHAPTER 56 The Nobel Prize / / EPILOGUE / / Acknowledpents / Notes / Index / Image Credits